Table 2.

Selectivity of SS148 and DS0464.

Methyltransferase	IC50 (µM)a
	SS148	DS0464
PRMT1	3 ± 0.07	NI
PRMT3	2 ± 0.07	NI
PRMT4	1 ± 0.1	10 ± 0.8
PRMT5	9 ± 2	13 ± 1.2
PRMT6	1 ± 0.2	NI
PRMT7	0.3 ± 0.03	14 ± 1.3
PRMT8	2 ± 0.05	NI
PRMT9	39 ± 4	NI
DOT1L	0.1 ± 0.009	7 ± 0.2
DNMT1	2 ± 0.3	NI
DNMT3A/3L	0.1 ± 0.002	NI
DNMT3B/3L	0.03 ± 0.006	NI
METTL3-METTL14	0.9 ± 0.1	NI
SETD3	NI	NI
BCDIN3D	0.03 ± 0.002	46 ± 9
Nsp14	0.07 ± 0.006	1.1 ± 0.2

NI, no inhibition.

^aIC₅₀ values are presented as the mean ± standard deviation (n = 3).