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. 2021 Sep 9;9:733573. doi: 10.3389/fcell.2021.733573

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Copyright © 2021 Locatelli and Maier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of microgravity and cytoskeletal disruption in 1g on transient receptor potential melastatin 7 (TRPM7) in human endothelial cell from umbilical vein (HUVEC) and human dermal microvascular endothelial cell (HDMEC) the levels of TRPM7 were analyzed by western blot in HUVEC (A,C) and HDMEC (B,D) exposed to simulated microgravity [panels (A,B), respectively] or to CYT D in 1g condition [panels (C,D) respectively]. Control loading was used to normalize, and the densitometric analysis is reported. *P < 0.05 and **P < 0.01.