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. 2021 Sep 23;13(9):655–675. doi: 10.1007/s13238-021-00871-6

Figure 4.

Figure 4

Comparison of XG014 epitopes with other antibodies that bind all-“down” SARS-CoV-2 S trimers. (A) Surface representation of two adjacent RBDs (labeled as RBD and RBD’) in all closed S trimers. ACE2 binding residues are colored pink, and the hot mutation sites 417, 484 and 501 are colored red. (B–H) Surface representation of two adjacent RBDs, in all closed S trimers, including XG014 (this study) (Zhou et al., 2021b), S2M11 (PDB ID: 7K43) (Tortorici MA, 2020), C144 (PDB ID: 7K90) (Barnes et al., 2020), COVOX-316 (PDB ID: 7ND7) (Dejnirattisai et al., 2021), 2-4 (PDB ID: 6XEY) (Liu et al., 2020a), 1-57 (PDB ID: 7LS9) (Cerutti et al., 2021) and S309 (PDB ID: 6WPS) (Pinto et al., 2020). The epitopes for each indicated antibody are colored as blue