Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 23;13(9):655–675. doi: 10.1007/s13238-021-00871-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Cryo-EM structure of SARS-CoV-2 S trimer complexed with XG005. (A) Molecular surface representation of the SARS-CoV-2 S-XG005 complex structure with three RBDs “down”, viewed along two orthogonal orientations. Each SARS-CoV-2 protomer is colored distinctly (cyan, green and yellow). The XG005 light and heavy chains are colored light orange and dark orange, respectively. (B) Cartoon representation of XG005-RBD regions. (C) Key interactions between XG005 and SARS-CoV-2 RBD. Hydrogen bonds are represented by dashed lines. (D) Positioning of ACE2 (pink) relative to the XG005 bound to SARS-CoV-2 RBD. (E) Comparison of XG014-RBD (XG014: purple; RBD: light gray) and XG005-RBD (XG005: orange; RBD: cyan) structures. (F) Molecular surface representation of the SARS CoV-2 RBD (cyan), showing the difference and similarity of XG005 and XG014 epitopes. The common residues involved in both XG005 and XG014 interactions are colored red. The specific residues involved in XG005 or XG014 binding are colored orange or purple, respectively