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. 2021 Sep 23;13(9):655–675. doi: 10.1007/s13238-021-00871-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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XG014 is protective and therapeutic against SARS-CoV-2 in vivo. (A) Diagram of prophylaxis and treatment protocols. (B) Body weight changes in prophylaxis, treatment and control groups. (C and D) SARS-CoV-2 viral mRNA titers in lungs (C) and intestines (D) four days post-challenge. RT-qPCR was used to quantify the SARS-CoV-2 viral mRNA load. (E and F) Dot plot showing the correlations between body weight changes (x axis) and SARS-CoV-2 viral mRNA titers (y axis) in lungs (E) and intestines (F). Spearman’s rank correlation coefficient (r) and significance value (P). (G) Histopathological staining of mouse lungs from the prophylaxis, treatment, and control groups. (H) mRNA levels of cytokines and chemokines, such as IFN-β, CCL-2, IL-6, and IL-1β in lungs four days post-infection. The statistical differences (P values) in this figure were all determined by Wilcoxon rank-sum test