Table 1.
Comparison of antibodies that bind all-“Down” SARS-CoV-2 S trimers. N/D, not determined
| IC50 | Cross-neutralization activities | Overlapping with RBM region | Overlapping with escape mutations such as E484 | Block all RBD in the "down" conformation | Interaction with 1 or 2 RBDs simultaneously | ||
|---|---|---|---|---|---|---|---|
| S2M11 (Tortorici MA, 2020) |
SARS-CoV-2 3 ng/mL |
SARS-CoV | - | Yes | Yes | Yes | Two |
| SARSr-CoV WIV1 | N/D | ||||||
| B.1.351 | - | ||||||
| P.1 | - | ||||||
| C144 (Barnes et al., 2020) |
SARS-CoV-2 2.55 ng/mL |
SARS-CoV | - | Yes | Yes | Yes | Two |
| SARSr-CoV WIV1 | - | ||||||
| B.1.351 | - | ||||||
| P.1 | - | ||||||
| COVOX-316 (Dejnirattisai et al., 2021) |
SARS-CoV-2 10 ng/mL |
SARS-CoV | N/D | Yes | Yes | Yes | One |
| SARSr-CoV WIV1 | N/D | ||||||
| B.1.351 | - | ||||||
| P.1 | - | ||||||
| 2-4 (Liu et al., 2020a) |
SARS-CoV-2 57 ng/mL |
SARS-CoV | N/D | Yes | Yes | Yes | One |
| SARSr-CoV WIV1 | N/D | ||||||
| B.1.351 | - | ||||||
| P.1 | - | ||||||
| 1-57 (Cerutti et al., 2021) |
SARS-CoV-2 8 ng/mL |
SARS-CoV | N/D | Yes | Weak interaction | Yes | One |
| SARSr-CoV WIV1 | N/D | ||||||
| B.1.351 | + | ||||||
| P.1 | + | ||||||
| S309 (Pinto et al., 2020) |
SARS-CoV-2 79 ng/mL |
SARS-CoV | + | No | No | No | One |
| SARSr-CoV WIV1 | + | ||||||
| B.1.351 | + | ||||||
| P.1 | N/D | ||||||
| XG014 (Zhou et al., 2021b) |
SARS-CoV-2 7 ng/mL |
SARS-CoV | + | No | No | Yes | Two |
| SARSr-CoV WIV1 | + | ||||||
| B.1.351 | + | ||||||
| P.1 | + | ||||||