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. 2021 Sep 9;12:732612. doi: 10.3389/fimmu.2021.732612

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Copyright © 2021 Lu, Sun, Yang, Fan, Huang, Hong, Wu, Zhou, Fang, Li, Meng, Huang and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sepsis patients exhibit increased levels of late apoptosis on DC subsets rather than on monocytes. (A) Flow detection of apoptosis of DC subsets. (B) Percentage of early apoptotic pDC and late apoptotic/dead pDC from healthy donors(n = 10), sepsis 1-2d (n = 16) and sepsis 3-7d (n = 8). (C) Percentage of early apoptotic CD1c⁺cDC and late apoptotic/dead CD1c⁺cDC from healthy donors (n = 10), sepsis 1-2d (n = 21) and sepsis 3-7d (n = 14). (D) Percentage of early apoptotic monocytes and late apoptotic/dead monocytes from healthy donors (n = 30), sepsis 1-2d (n = 22) and sepsis 3-7d (n = 12). Error bars indicate mean ± SD. *P < 0.05; **P < 0.01; ****P < 0.0001.