Table 1.

Potential mechanisms of eccDNA formation and corresponding references.

Number of mechanism	EccDNA type	Reference type	References	DOI
1	ERC	Review	Nelson et al. (40)	https://doi.org/10.1016/j.tig.2019.07.006
		Article	Yerlici et al. (41)	https://doi.org/10.1093/nar/gkz725
	t-circle	Review	Tomaska et al. (42)	https://doi.org/10.1016/j.febslet.2004.04.058
		Article	Yerlici et al. (41)	https://doi.org/10.1093/nar/gkz725
	MicroDNA	Article	Dillon et al. (35)	https://doi.org/10.1016/j.celrep.2015.05.020
		Article	Yerlici et al. (41)	https://doi.org/10.1093/nar/gkz725
2	ERC	Article	Park et al. (43)	https://doi.org/10.1128/MCB.19.5.3848
	ecDNA	Article	Gresham et al. (44)	https://doi.org/10.1073/pnas.1014023107
	MicroDNA	Review	Paulsen et al. (45)	https://doi.org/10.1016/j.tig.2017.12.010
3	ERC	Article	Hull et al. (34)	https://doi.org/10.1371/journal.pbio.3000471
	t-circle	Review	Tomaska et al. (42)	https://doi.org/10.1016/j.febslet.2004.04.058
		Article	Hull et al. (34)	https://doi.org/10.1371/journal.pbio.3000471
4	t-circle	Review	Tomaska et al. (42)	https://doi.org/10.1016/j.febslet.2004.04.058
	ecDNA	Review	Gu et al. (46)	https://doi.org/10.1186/s13046-020-01726-4
		Review	Yan et al. (47)	https://doi.org/10.1186/s13045-020-00960-9
5	ecDNA	Review	Gu et al. (46)	https://doi.org/10.1186/s13046-020-01726-4
		Review	Yan et al. (47)	https://doi.org/10.1186/s13045-020-00960-9
		Review	Liao et al. (48)	https://doi.org/10.1016/j.bbcan.2020.188392
6	DM	Review	Gu et al. (46)	https://doi.org/10.1186/s13046-020-01726-4
		Review	Yan et al. (47)	https://doi.org/10.1186/s13045-020-00960-9
		Review	Liao et al. (48)	https://doi.org/10.1016/j.bbcan.2020.188392
7	MicroDNA	Article	Dillon et al. (35)	https://doi.org/10.1016/j.celrep.2015.05.020
		Review	Paulsen et al. (45)	https://doi.org/10.1016/j.tig.2017.12.010
8	MicroDNA	Article	Dillon et al. (35)	https://doi.org/10.1016/j.celrep.2015.05.020
		Review	Paulsen et al. (45)	https://doi.org/10.1016/j.tig.2017.12.010
9	MicroDNA	Article	Dillon et al. (35)	https://doi.org/10.1016/j.celrep.2015.05.020
		Review	Paulsen et al. (45)	https://doi.org/10.1016/j.tig.2017.12.010
10	ERC	Article	Mansisidor et al. (49)	https://doi.org/10.1016/j.molcel.2018.08.036
	DM	Article	Vogt et al. (50)	https://doi.org/10.1073/pnas.0402979101
		Review	Wei et al. (51)	https://www.ncbi.nlm.nih.gov/pubmed/33294253
11	MicroDNA	Review	Paulsen et al. (45)	https://doi.org/10.1016/j.tig.2017.12.010
		Review	Ain et al. (52)	https://doi.org/10.3390/ijms21072477