Figure 14.

Genes related to T cell receptor signaling are differentially expressed in CD4⁺ T cells from the CNS of microglia-deficient B6J mice compared to microglia-deficient SJL mice. C57BL/6J and SJL/J mice were treated with a PLX5622-supplemented diet seven days prior to i.c. TMEV infection and sacrificed at 6 DPI for analysis (n = 10 mice per group). Volcano plot of RNA-seq transcriptome data and KEGG map display T cell receptor signaling-related gene expression in enriched CD4⁺ T cells from the CNS of microglia-deficient C57BL/6J mice relative to microglia-deficient SJL/J mice.