Figure 8.

Genes related to cytokine-cytokine receptor interaction, JAK/STAT signaling, and T cell receptor signaling are enriched in CD4⁺ and CD8⁺ T cells from the CNS of microglia-deficient B6J mice compared to microglia-competent B6J mice. C57BL/6J mice were treated with a PLX5622-supplemented or control diet seven days prior to i.c. TMEV infection and sacrificed at 6 DPI for analysis (n = 10 mice per group). Volcano plots of RNA-seq transcriptome data displaying gene expression within the indicated KEGG pathways of enriched CD4⁺ and CD8⁺ T cells from the CNS of microglia-deficient C57BL/6J mice relative to microglia-competent C57BL/6J mice.