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. 2021 Sep 9;12:735125. doi: 10.3389/fimmu.2021.735125

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Copyright © 2021 Du, Wei, Li, Hua, Sun, Wang, Han, Yan, Song, Song, Zhang, Han, Liu and Kong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HLA-DR⁺CD38^hi CD8⁺ T cells displayed phenotypic and transcriptional state of exhaustion. (A–D) Flow cytometry analysis of expression of PD-1 (A), TIM3 (B), LAG3 (C), and TIGIT (D) on the three CD8⁺ T population (I, II, III) from COVID-19 patients (n = 20). Representative histograms (left) and plots (right) were shown. (E) Representative flow data (left) and dot plots (right) of percentage of T-bet^dimEomes^hi and T-bet^hiEomes^dim cells among I, II, III from COVID-19 patients (n = 20). P Values were obtained by paired two-tailed Student’s t tests and repeated measures by one-way ANOVA test followed by Holm-Sidak’s multiple comparisons test. **p < .01, ***p < .001, ****p < .0001.