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. 2021 Sep 9;11:682710. doi: 10.3389/fonc.2021.682710

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Copyright © 2021 Wang, Gao, Hu, Zeng, Yang, Chen and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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siRNA-mediated knockdown of SLC25A21 promotes BCa cell proliferation, migration and invasion, and represses cell apoptosis in vitro. (A, B) Depletion of SLC25A21 after transient transfection of siRNA targeting SLC25A21 was confirmed in two BCa cell lines by real-time RT-PCR (A) and western blotting (B). (C, D) The effects of SLC25A21 downregulation on BCa cell proliferation by CCK-8 (C) and colony formation assays (D). (E) The effects of SLC25A21 depletion on cell apoptosis (E) by flow cytometry. (F) The effects of SLC25A21 depletion on the migration ability of BCa cells by using a wound healing assay. (G) Invasion assays were used to determine the effects of SLC25A21 depletion on the invasion ability of BCa cells. Representative images (left) and quantitative analyses (right) are shown. Data are expressed as the means ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.