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Process of development of AOP includes chemical initiators (chemical or NPs or nanotubes) which will bind to receptor, protein, or DNA causing cascade impact on the signaling pathway. The initial interaction with biological system is the molecular initiating event (MIE), which further leads to the development of key events (KEs) and finally causes apical adverse outcome (AO). The relationship between the two key events is designated as key event relationships (KER).
