Table 2.

Discriminated metabolites and their pathways from pathway analysis

Pathway	Metabolites	Total	Hits	p-value	FDR	Impact
Tryptophan metabolism	5-N-Acetylserotonin; Methoxytryptamine; 5-Hydroxyindoleacetate; Melatonin; Indole-3-acetamide; Indole-3-acetate; Anthranilate; 3-Hydroxyanthranilate; Xanthurenic acid	79	9	$<$ 0.001	0.000306	0.22
Tyrosine metabolism	L-Tyrosine; 4-Hydroxyphenylpyruvate; Phenol; Formamide; Triiodothyronine; Hydroquinonecarboxylic acid; gentisate; 3,4Dihydroxyphenylpropanoate	76	7	$<$ 0.001	0.00454	0.13
Phenylalanine, tyrosine, and tryptophan biosynthesis	3,4-Dihydroxybenzoic acid; Anthranilic acid; 4-Hydroxyphenylpyruvate; L-Tyrosine	27	4	$<$ 0.001	0.00674	0.08
Phenylalanine metabolism	Phenethylamine; Phenylacetic acid; 2-Hydroxyphenylacetate L-Tyrosine	45	4	0.01	0.0320	0.06
Ubiquinone and another terpenoid-quinone biosynthesis	3-(4-Hydroxyphenyl) pyruvate; L-Tyrosine	36	2	0.19	0.0187	0.05
Nitrogen metabolism	Anthranilate; L-Tyrosine	39	2	0.21	1.55	0.00
Thiamine metabolism	L-Tyrosine	24	1	0.41	0.0878	0.00
Aminoacyl-tRNA biosynthesis	L-Tyrosine	75	1	0.81	0.0203	0.00
Porphyrin and chlorophyll metabolism	Bilirubin	104	1	0.90	0.0984	0.01
Total: Total number of compounds in the pathway, Hits: Matched number from the user uploaded data, P-value: Original p-value calculated from the enrichment analysis, FDR: P-value adjusted using false discovery rate, Impact: Pathway impact value calculated from pathway topology analysis