Table 3.
Co-expression % of NK3 receptors or κ-opioid receptors in the arcuate kisspeptin/neurokinin B neurons.
| Species | Sexes and treatments | NK3R | KOR | Targets | Methods | Reference no. and authors |
|---|---|---|---|---|---|---|
| Sheep | Female (Ovary intact)1 | 64% | – | NKB | IHC | (116), Amstalden, et al., 2010 |
| Female (Ovary intact)1 | – | 97.8% | Kp | IHC | (118), Weems et al., 2016 | |
| Female (Ovary intact)1 | – | 93.5% | NKB | IHC | (118), Weems et al., 2016 | |
| Rats | Female (OVX+E2) | – | 62% | Kp | ISH | (117), Tsuchida et al., 2020 |
| Mice | Female (OVX/OVX+E2) | 96% | 20% | Kp | ISH | (7), Navarro et al., 2009 |
| Male (Cast/Cast+T) | 76% | 6% | Kp | ISH | (8), Navarro et al., 2011 | |
| Male (Testis intact)2 | 35% | 41% | NKB | Single-cell PCR | (115), Ruka et al., 2013 | |
| Male (Cast)2 | 86% | 19% | NKB | Single-cell PCR | (115), Ruka et al., 2013 | |
| Female (OVX)3 | 83% | 33% | Kp | Pooled cell PCR | (11), Ikegami et al., 2017 |
Cast, castration; E2, estradiol-17β; Kp, kisspeptin; KOR, κ-opioid receptors; NK3R, NK3 receptors; NKB, neurokinin B; OVX, ovariectomy; T, testosterone.
1Data were collected from ewes at the luteal stage.
2Data were collected from Tac2-GFP transgenic mice.
3Data were collected from Kiss1-GFP transgenic mice.