Table 1.

Shows senescence-associated mitomiR targets.

SA-mitomiRs	Cytosolic target	Effect on senescence-related pathways	Mt-DNA target	Effect on mitochondrial functions
miR-21-5p	-NFIB and CDC25A (Dellago et al., 2013) -TLR8 (ligand; Zhang et al., 2018) -A20 (Xue et al., 2019) -PTEN (Buscaglia and Li, 2011; Ma et al., 2013) -PDCD4 (Matsuhashi et al., 2019)	-Cell proliferation arrest-Pro-inflammatory cytokine production-Activation of NF- κB pathway and NLRP3 inflammasome	-mt-Cyb (Li et al., 2016)	-enhanced mitochondrial translation
miR-146a-5p	-TLR4 (Xiao et al., 2019) -TRAF6 (Taganov et al., 2006) -IRAK1 (Taganov et al., 2006) -BCL2 (Giuliani et al., 2018)	-Pro-inflammatory cytokine production-Apoptosis sensitivity alteration-Activation of NF-κB pathway	-mt-ND1, mt-ND2, mt-ND4, mt-ND5, mt-ND6; -mt-ATP8 (PREDICTED; Dasgupta et al., 2015)
miR-181a-5p	-SIRT1 (Di Val Cervo et al., 2012) -BCL2 (Giuliani et al., 2018) -PARK2 and p62/SQSTM1 (Goljanek-Whysall et al., 2020)	-Cell proliferation arrest-Apoptosis sensitivity alteration-Impaired autophagy
miR-210	-NDUFA4 and SDHD (Puisségur et al., 2011) -ISCU1/2 (Chan et al., 2009)-RAD52 (Crosby et al., 2009) -E2F3 (Biswas et al., 2010)	-Mitochondrial dysfunction-DNA repair loss - Cell proliferation arrest
miR-34a	-SIRT1/P53 axis-BCL2 (Giuliani et al., 2018) -Txnrd2 (Bai et al., 2011)	-Apoptosis sensitivity alteration-Cell proliferation arrest-Pro-inflammatory cytokine production-Increased oxidative stress

Tumor necrosis factor, alpha-induced protein 3(A20); B-cell lymphoma 2 (Bcl-2); Cell division cycle 25 A(CDC25A); E2F transcription factor 3 (E2F3); Interleukin 1 Receptor Associated Kinase 1 (IRAK1); Iron–sulfur cluster assembly enzyme (ISCU); mtDNA-encoded cytochrome b (mt-Cytb); Nuclear factor 1 B-type (NFIB); Phosphatase and tensin homolog (PTEN); succinate dehydrogenase complex subunit D (SDHD); Sirtuin 1 (SIRT1); Sequestosome-1 (SQSTM1); Toll like receptor (TLR); TNF Receptor Associated Factor 6 (TRAF6); Thioredoxin Reductase 2 (Txnrd2).