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. 2021 Sep 9;12:722476. doi: 10.3389/fphar.2021.722476

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Copyright © 2021 He, Galaj, Bi, He, Hempel, Wang, Gardner and Xi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of BCP on METH-enhanced electrical brain-stimulation reward (BSR) in rats (n = 12). (A): A diagram showing that electrical stimulation of the medial forebrain bundle at the hypothalamus produces BSR. (B): Representative stimulation–response curves, indicating that METH treatment shifted the stimulation-response curve to the left and decreased the BSR stimulation threshold (θ₀ value) but not M50; (C): Averaged % changes in BSR stimulation threshold (θ₀ value), indicating that BCP pretreatment significantly attenuated METH-induced reduction in the θ₀ value. (D): BCP did not produce a significant reduction in M50. (E): METH and BCP did not produce a significant change in Ymax. *p < 0.05, compared to the vehicle group.