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. 2021 Sep 9;12:722476. doi: 10.3389/fphar.2021.722476

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Copyright © 2021 He, Galaj, Bi, He, Hempel, Wang, Gardner and Xi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of BCP on METH-associated cue-induced drug seeking in rats after forced abstinence. (A): Systemic administration of BCP (25, 50, 100 mg/kg, i.p., 30 min prior to test) dose-dependently inhibited cue-triggered drug-seeking in rats after 3 weeks of withdrawal from METH self-administration. (B): BCP, at the same doses, failed to alter inactive lever responses during cue exposure test. Data are presented as means ± SEM. *p < 0.05, ***p < 0.001, when compared to the vehicle group.