Table 1.

Summary of pharmacological regulation of MC3R signaling by selective GPCRs.

NO	Gene Name	Maximal response	Antagonism	Surface translocation	NO	Gene Name	Maximal response	Antagonism	Surface translocation	NO	Gene Name	Maximal response	Antagonism	Surface translocation
1	ADRA1B	NT	NT		16	NTSR1		NS		31	HTR2C	–	–	–
2	ADRB2	NT	NT	NS	17	NTSR2		NS		32	NPFFR1	–	–	–
3	ADRB3	NT	NT		18	OXTR				33	NPFFR2	–	–	–
4	CRHR1	NT	NT	NS	19	PRLH				34	NPY2R	–	–	–
5	CXCR4		NS		20	PTGER2	NT	NT		35	NPY5R	–	–	–
6	C3AR1				21	PTGER3			NS	36	OPRLR	–	–	–
7	GPRC5B	NT	NT		22	SSTR1			NS	37	PROKR1	–	–	–
8	GPR19		NS		23	SSTR2	NS	NS		38	PTGER1	–	–	–
9	GPR88				24	FFAR1	–	–	–	39	PTGER4	–	–	–
10	GPR146	NT	NT		25	GHR	–	–	–	40	QRFPR	–	–	–
11	GPR150	NT	NT		26	GLP1R	–	–	–	41	SSTR3	–	–	–
12	LPAR1				27	GPR26	–	–	–	42	SSTR5	–	–	–
13	MCHR1				28	GPR63	–	–	–	43	TRHR	–	–	–
14	NMUR2				29	GPR75	–	–	–	44
15	NPY1R				30	GPR83	–	–	–	45

NT: not tested in this experiment; NS: no significant difference; ↑: up-regulation; ↓: down-regulation; --: negative results.