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. 2021 Sep 9;12:697349. doi: 10.3389/fneur.2021.697349

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Copyright © 2021 Feng, Li, Tan, Liang, Ma, Chen, Lv, Wu, Kang, Li and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Differences in GMV between patients with early-onset T2DM and HCs. AlphaSim correction (5,000 simulations, voxel p = 0.001, and cluster size ≥ 586 voxels). (B) Comparison of DC values between the two groups. Cluster-level FWE correction (p < 0.05, cluster size ≥ 80 voxels). (C) Comparison of FC values between the two groups. Cluster-level FWE correction (p < 0.05, cluster size ≥ 90 voxels). The color bar denotes the t-value. GMV, gray matter volume; T2DM, type 2 diabetes mellitus; HCs, healthy controls; DC, degree centrality; FWE, familywise error; FC, functional connectivity.