Table 2.
Comparison of GMV, DC, and FC between early-T2DM and HC groups.
| Cluster | Regions | Peak MNI | Number of voxels | t-value | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| VBM | ||||||
| Cluster 1 | Frontal_Sup_R | 12 | 70.5 | 3 | 172 | −5.1108 |
| Frontal_Sup_Orb_R | 169 | |||||
| Frontal_Mid_Orb_R | 128 | |||||
| Cluster 2 | Frontal_Mid_Orb_L | −39 | 42 | −9 | 241 | 5.0316 |
| Frontal_Inf_Orb_L | 109 | |||||
| Frontal_Sup_Orb_L | 102 | |||||
| Degree centrality | ||||||
| Cluster 1 | L_STG | −42 | −21 | −12 | 22 | 5.6034 |
| L_HES | 11 | |||||
| L_HIP | 3 | |||||
| Functional connectivity | ||||||
| Cluster 1 | R_PoCG | 39 | −15 | 0 | 122 | 5.1308 |
| R_STG | 111 | |||||
| R_INS | 79 | |||||
| Cluster 2 | L_STG | −39 | −30 | −6 | 117 | 5.5411 |
| L_INS | 90 | |||||
| L_HES | 39 | |||||
| Cluster 3 | L_MCG | −15 | −48 | 42 | 239 | 6.1663 |
| R_MCG | 200 | |||||
| R_PRUN | 168 | |||||
| Cluster 4 | L_PoCG | −36 | −27 | 39 | 65 | 4.8955 |
| L_IPL | 18 | |||||
GMV, gray matter volume; DC, degree centrality; FC, functional connectivity; T2DM, type 2 diabetes mellitus; HC, healthy control; MNI, Montreal Neurological Institute; VBM, voxel-based morphology; Frontal_Sup_Orb_R, right orbital superior frontal gyrus; Frontal_Sup_R, right superior frontal gyrus; Frontal_Mid_Orb_R, right medial orbital superior frontal gyus; Frontal_Mid_Orb_L, left orbital middle frontal gyrus; Frontal_Inf_Orb_L, left orbital inferior frontal gyrus; Frontal_Sup_Orb_L, left orbital superior frontal gyrus; STG, superior temporal gyus; PoCG, postcentral gyrus; INS, insular; HES, Heschl; MCG, midcingulate gyrus; IPL, inferior parietal lobule; PCUN, precuneus; HIP, hippocampus.