Table 3.
comparison between migraine and control group through genetic models.
| SNP | Model |
Allele/ Genotype |
Migraine N = 127 % |
Control N = 120 % |
P value |
Crude Analysis COR(95% Cl) |
¤Adjusted Analysis AOR(95% Cl) |
P value |
|---|---|---|---|---|---|---|---|---|
|
rs2651899 (PRDM16) |
Allele | A | 137(53.94) | 188(78.33) | <0.001*** | 3.088(2.082–4.579) | ||
| G | 117(46.06) | 52(21.67) | ||||||
|
Genotype |
AA | 34(26.77) | 78(65) | |||||
| AG vs. AA | 69(54.33) | 32(26.67) | <0.001*** | 4.947(2.766– 8.847) |
5.452(2.983–9.965) | <0.001*** | ||
| GG vs. AA | 24(18.90) | 10(8.33) | <0.001*** | 5.506(2.376–12.760) | 5.394(2.319–12.550) | <0.001*** | ||
| Dominant | AA | 34(26.77) | 78(65) | |||||
| AG + GG | 93(73.23) | 42(35) | <0.001*** | 5.080(2.951–8.744) | 5.437(3.112–9.498) | <0.001*** | ||
|
rs11172113 (LRP1) |
Allele | T | 145(57.09) | 166(69.16) | 0.0055*** | 1.686(1.165–2.441) | ||
| C | 109(42.91) | 74(30.83) | ||||||
|
Genotype |
TT | 38(29.92) | 53(44.16) | |||||
| CT vs. TT | 69(54.33) | 60(50) | 0.087 | 1.604(0.93–2.757) | 1.749(0.996–3.073) | 0.52 | ||
| CC vs. TT | 20(15.75) | 07(5.84) | 0.005** | 3.985(1.582–10.369) | 3.977(1.524–10.375) | 0.005** | ||
| Dominant | TT | 38(29.92) | 53(44.16) | |||||
| CT + CC | 89(70.08) | 67(55.84) | 0.021* | 1.853(1.098–3.127) | 2.028(1.180–3.487) | 0.011* | ||
| rs10166942 (TRPM8) | Allele | T | 189(74.41) | 198(82.5) | 0.0291* | 1.621(1.048–2.508) | ||
| C | 65(25.59) | 42(17.5) | ||||||
|
Genotype |
TT | 70(55.12) | 84(70) | |||||
| CT vs. TT | 49(38.58) | 30(25) | 0.017* | 1.960(1.126–3.411) | 2.044(1.63–3.594) | 0.013* | ||
| CC vs. TT | 08(6.30) | 06(5) | 0.404 | 1.600(0.530–4.831) | 1.484(0.489–4.511) | 0.486 | ||
| Dominant | TT | 70(55.12) | 84(70) | |||||
| CT + CC | 57(44.88) | 36(30) | 0.016* | 1.900(1.125–3.209) | 1.943(1.143–3.305) | 0.014* |
Data presented as number (N) and percentage (%)
COR; Crude odds ratio, AOR; Adjusted odds ratio Cl; Confidence Interval
*p < 0.05, **p < 0.01, ***p < 0.001 statistically significant
Adjusted for age and sex