TABLE 1.
In vitro susceptibilities of 71 Candida dubliniensis isolates tested against eight antifungal agents
| Antifungal agent | MIC (μg/ml)
|
% Sa | ||
|---|---|---|---|---|
| Range | MIC50 | MIC90 | ||
| Fluconazole | 0.12–64 | 0.25 | 8.0 | 97 |
| Itraconazole | 0.015–0.5 | 0.06 | 0.25 | 100 |
| BMS-207147 | ≤0.008–0.25 | ≤0.008 | 0.03 | 100 |
| Sch 56592 | 0.015–0.12 | 0.03 | 0.06 | 100 |
| Voriconazole | ≤0.008–0.5 | ≤0.008 | 0.03 | 100 |
| MK-0991 | 0.03–1.0 | 0.25 | 0.5 | 99 |
| Amphotericin B | 0.05–0.38 | 0.19 | 0.25 | 100 |
| 5FC | ≤0.12 | ≤0.12 | ≤0.12 | 100 |
a
% S, percentage of strains susceptible to the indicated antifungal agent at the following threshold concentration: fluconazole, <64 μg/ml; itraconazole, BMS-207147, Sch 56592, voriconazole, MK-0991, and amphotericin B, <1.0 μg/ml; or 5FC, <8.0 μg/ml.