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. 2021 Sep 18;15:3953–3963. doi: 10.2147/DDDT.S325790

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© 2021 Li et al.

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CpG2018B induces cytokine expression and tumor regression in melanoma mouse models. (A) Tumor growth was monitored after intratumoral injection of CpGs into melanoma mouse models. (B) and (C) After sacrifice, tumors were photographed and weighed. (D–F) The IFN-γ, TNFα and IL-6 mRNA levels in tumor samples were analyzed by qPCR. (G) Tumors were embedded in paraffin and stained with H&E or antibodies specific for CD4, CD8 and TLR9. *p<0.5, **p<0.01.