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. 2021 Sep 18;15:3953–3963. doi: 10.2147/DDDT.S325790

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© 2021 Li et al.

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CpG2018B was combined with an LNP-formulated mRNA vaccine to treat melanoma models. (A) Tumor growth was monitored after intratumoral injection of CpGs, an mRNA vaccine or CpG+the mRNA vaccine into melanoma mouse models (n=5). (B and C) After sacrifice, tumors were photographed and weighed. (D) Tumor samples were halved, with one half used for cell isolation, and CD8-positive T cells were gated by FACS. (E) Tumors were embedded in paraffin and stained with H&E or antibodies specific for CD4, CD8 and TLR9. *p<0.5, **p<0.01.