Table 1. Demographic and Pathologic Characteristics of the Study Population and Their Differences in 3 TIL Grades.
Characteristic | No. (%) | P valuea | |||
---|---|---|---|---|---|
Total (N = 2624) | TIL grade | ||||
Absent (n = 434) | Nonbrisk (n = 1916) | Brisk (n = 274) | |||
Age, median (IQR), y | 61 (50-72) | 63 (52-72) | 61 (50-72) | 58 (47-67) | .002 |
<50 | 642 (24.5) | 90 (20.7) | 472 (24.6) | 80 (29.2) | .009 |
50-69 | 1258 (47.9) | 219 (50.5) | 899 (46.9) | 140 (51.1) | |
≥70 | 724 (27.6) | 125 (28.8) | 545 (28.4) | 54 (19.7) | |
Sex | |||||
Female | 1162 (44.3) | 200 (46.1) | 829 (43.3) | 133 (48.5) | .18 |
Male | 1462 (55.7) | 234 (53.9) | 1087 (56.7) | 141 (51.5) | |
Breslow thickness, median (IQR), mmb | 1.2 (0.7-2.5) | 1.3 (0.7-2.9) | 1.2 (0.7-2.6) | 0.9 (0.6-1.5) | <.001 |
≤1 (T1) | 1082 (41.2) | 165 (38.0) | 759 (39.6) | 158 (57.7) | <.001 |
1.01 to 2 (T2) | 630 (24.0) | 103 (23.7) | 461 (24.1) | 66 (24.1) | |
2.01 to 4 (T3) | 423 (16.1) | 67 (15.4) | 325 (17.0) | 31 (11.3) | |
>4 (T4) | 403 (15.4) | 83 (19.1) | 303 (15.8) | 17 (6.2) | |
Unknown | 86 (3.3) | 16 (3.7) | 68 (3.5) | 2 (0.7) | |
Mitotic rate, median (IQR) | 2 (1-6) | 2 (1-6) | 2 (1-6) | 1 (0-3) | <.001 |
Ulceration | |||||
Absent | 2040 (77.7) | 352 (81.1) | 1448 (75.6) | 240 (87.6) | <.001 |
Present | 536 (20.4) | 76 (17.5) | 427 (22.3) | 33 (12.0) | |
Unknown | 48 (1.8) | 6 (1.4) | 41 (2.1) | 1 (0.4) | |
Histological regression | |||||
Absent | 1969 (75.0) | 381 (87.8) | 1439 (75.1) | 149 (54.4) | <.001 |
Present | 628 (23.9) | 49 (11.3) | 457 (23.9) | 122 (44.5) | |
Unknown | 27 (1.0) | 4 (0.9) | 20 (1.0) | 3 (1.1) | |
Microscopic satellites | |||||
Absent | 1387 (52.9) | 225 (51.8) | 1003 (52.3) | 159 (58.0) | .007 |
Present | 65 (2.5) | 15 (3.5) | 50 (2.6) | 0 (0.0) | |
Unknown | 1172 (44.7) | 194 (44.7) | 863 (45.0) | 115 (42.0) | |
Vascular/lymphatic invasion | |||||
Absent | 177 (6.7) | 56 (12.9) | 112 (5.8) | 9 (3.3) | <.001 |
Present | 1468 (55.9) | 250 (57.6) | 1092 (57.0) | 126 (46.0) | |
Unknown | 979 (37.3) | 128 (29.5) | 712 (37.2) | 139 (50.7) |
Abbreviations: IQR, interquartile range; TIL, tumor-infiltrating lymphocyte.
The Kruskal-Wallis rank test was used for continuous variables, the χ2 test was used for sex and vascular or lymphatic invasion, and the Fisher exact test was used for the characteristics with fewer than 5 patients (ie, Breslow thickness category, ulceration, histologic regression, and microscopic satellites).
Based on American Joint Committee on Cancer staging: T1, Breslow thickness 1.0 mm or less; T2, Breslow thickness 1.01 to 2.0 mm; T3, Breslow thickness 2.01 to 4.0 mm; and T4, Breslow thickness greater than 4.0 mm.