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. 2021 Sep 22;4(9):e2126337. doi: 10.1001/jamanetworkopen.2021.26337

Table 1. Demographic and Pathologic Characteristics of the Study Population and Their Differences in 3 TIL Grades.

Characteristic No. (%) P valuea
Total (N = 2624) TIL grade
Absent (n = 434) Nonbrisk (n = 1916) Brisk (n = 274)
Age, median (IQR), y 61 (50-72) 63 (52-72) 61 (50-72) 58 (47-67) .002
<50 642 (24.5) 90 (20.7) 472 (24.6) 80 (29.2) .009
50-69 1258 (47.9) 219 (50.5) 899 (46.9) 140 (51.1)
≥70 724 (27.6) 125 (28.8) 545 (28.4) 54 (19.7)
Sex
Female 1162 (44.3) 200 (46.1) 829 (43.3) 133 (48.5) .18
Male 1462 (55.7) 234 (53.9) 1087 (56.7) 141 (51.5)
Breslow thickness, median (IQR), mmb 1.2 (0.7-2.5) 1.3 (0.7-2.9) 1.2 (0.7-2.6) 0.9 (0.6-1.5) <.001
≤1 (T1) 1082 (41.2) 165 (38.0) 759 (39.6) 158 (57.7) <.001
1.01 to 2 (T2) 630 (24.0) 103 (23.7) 461 (24.1) 66 (24.1)
2.01 to 4 (T3) 423 (16.1) 67 (15.4) 325 (17.0) 31 (11.3)
>4 (T4) 403 (15.4) 83 (19.1) 303 (15.8) 17 (6.2)
Unknown 86 (3.3) 16 (3.7) 68 (3.5) 2 (0.7)
Mitotic rate, median (IQR) 2 (1-6) 2 (1-6) 2 (1-6) 1 (0-3) <.001
Ulceration
Absent 2040 (77.7) 352 (81.1) 1448 (75.6) 240 (87.6) <.001
Present 536 (20.4) 76 (17.5) 427 (22.3) 33 (12.0)
Unknown 48 (1.8) 6 (1.4) 41 (2.1) 1 (0.4)
Histological regression
Absent 1969 (75.0) 381 (87.8) 1439 (75.1) 149 (54.4) <.001
Present 628 (23.9) 49 (11.3) 457 (23.9) 122 (44.5)
Unknown 27 (1.0) 4 (0.9) 20 (1.0) 3 (1.1)
Microscopic satellites
Absent 1387 (52.9) 225 (51.8) 1003 (52.3) 159 (58.0) .007
Present 65 (2.5) 15 (3.5) 50 (2.6) 0 (0.0)
Unknown 1172 (44.7) 194 (44.7) 863 (45.0) 115 (42.0)
Vascular/lymphatic invasion
Absent 177 (6.7) 56 (12.9) 112 (5.8) 9 (3.3) <.001
Present 1468 (55.9) 250 (57.6) 1092 (57.0) 126 (46.0)
Unknown 979 (37.3) 128 (29.5) 712 (37.2) 139 (50.7)

Abbreviations: IQR, interquartile range; TIL, tumor-infiltrating lymphocyte.

a

The Kruskal-Wallis rank test was used for continuous variables, the χ2 test was used for sex and vascular or lymphatic invasion, and the Fisher exact test was used for the characteristics with fewer than 5 patients (ie, Breslow thickness category, ulceration, histologic regression, and microscopic satellites).

b

Based on American Joint Committee on Cancer staging: T1, Breslow thickness 1.0 mm or less; T2, Breslow thickness 1.01 to 2.0 mm; T3, Breslow thickness 2.01 to 4.0 mm; and T4, Breslow thickness greater than 4.0 mm.