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. Author manuscript; available in PMC: 2021 Sep 23.
Published in final edited form as: Chem Rev. 2020 Sep 4;120(19):11093–11127. doi: 10.1021/acs.chemrev.0c00145

Figure 17. Midbrain Organoid.

Figure 17.

(A) Schematic diagrams illustrating the overall strategy to midbrain organoids.

(B) Fontana-Masson staining to reveal NM-like granules in both intra- (blue arrows) and extracellular compartments (black arrows) of the organoids compared with (C) Fontana-human midbrain tissue. (E) SEM image of isolated NM granules from the organoids, compared with (F) Huma midbrain tissue. (Reprinted with permission from ref244. Copyright 2016 Cell Stem Cell).