TABLE 1.
Studies included photo‐sensitive reactions occurred in patients
| Authors | Type of study | Year | No. of patients | Drug | Dose | Reaction |
|---|---|---|---|---|---|---|
| Acne | ||||||
| Pariser DM, Green LJ | RCT | 2019 | 1/483 | Sarecycline | 1.5 mg/kg/day | Sunburn |
|
Moore A, Green LJ, et al. |
RCT | 2018 | 1/513 | Sarecycline | 1.5 mg/kg/day | Photosensitivity |
|
Leyden JJ, Sniukiene V, Berk DR, Kaoukhov A |
RCT | 2018 | 10/212 | Sarecycline |
0.75 mg/kg/day 1.5 mg/kg/day 3 mg/kg/day |
Photosensitivity |
|
Kus S, Yucelten D, et al. |
RCT | 2005 | 2/26 | Doxycycline | 200 mg/day first month, 100 mg/day the following 2 months | Photosensitivity |
|
Sanchez J, Somolinos AL, et al. |
RCT |
2005 |
0/20 | Doxycycline | 20 mg | Photosensitivity |
|
Gruber F, Grubišić‐Greblo H, |
Open, non‐ randomized and comparative study | 1998 | 0/34 | Minocycline | 100 mg | Photosensitivity |
|
Goulden V, Glass D, et al. |
Prospective cohort study | 1996 | 7/700 | Minocycline | 100 daily, 100/200 on alternate days and 200 daily | Photosensitivity |
|
Layton AM, Cunlife WJ |
Prospective cohort study | 1993 |
38 /106 |
Doxycycline | 150–200 mg | Phototoxicity |
|
Hubbell CG, Hobbs ER, et al. |
RCT |
1982 |
0/25 | Minocycline |
100 mg |
Phototoxicity |
|
Hubbell CG, Hobbs ER, et al. |
RCT |
1982 |
0/24 | Tetracycline | 500 mg | Phototoxicity |
|
Cullen SI |
RCT | 1976 | 0/42 | Minocycline | 100 mg | Phototoxic |
|
Cullen SI |
RCT | 1976 | 0/40 | Tetracycline | 500 mg | Phototoxic |
|
Orentreich N, Harber L et al. |
Prospective cohort study | 1961 | 27/108 | Demethylchlortetracycline |
600 mg Furunculosis and folliculitis |
Phototoxic |
|
Fuhrman DL, Drowns B et al. |
Prospective cohort study | 1960 | 7/70 | Demethylchlortetracycline. |
600 mg/day Acne, sycosis barbae and other pyogenic infections |
Photosensitivity, polymorphous light eruption |
| Lyme disease | ||||||
|
Velušček M, Bajrović FF, et al. |
Prospective cohort study | 2018 |
16/858 |
Doxycycline | 200 mg/day | Photosensitivity |
|
Ogrinc K, Logar M, et al. |
Prospective cohort study | 2006 | 7/23 | Doxycycline | 200 mg/day | Photosensibility |
|
Strle F, Maraspin V, et al. |
Prospective cohort study | 1996 | 5/42 | Doxycycline | 200 mg/day |
Photosensitivity |
|
Luger SW, Paparone P, et al. |
RCT | 1995 | 7/113 | Doxycycline | 300 mg/day | Photosensitivity |
|
Nowakowski J, Nadelman RB, et al. |
RCT | 1995 | 4/38 | Doxycycline |
300 mg/day |
Photosensitivity |
|
Nadelman RB, Luger SW, et al. |
RCT | 1992 | 9/60 | Doxycycline | 300 mg/day | Photosensitivity |
| Gulf vet | ||||||
|
Donta ST, Engel CC Jr, et al. |
RCT | 2004 | 36/245 | Doxycycline | 200 mg/day | Photosensitivity |
| Traveler's diarrhea | ||||||
|
Hipskind JE |
Prospective cohort study | 1993 | 0/42 |
Doxycycline |
Not specified | Photosensitivity |
| Abdominal aortic aneurysms | ||||||
|
Baxter BT, Pearce WH, et al. |
Prospective cohort study | 2002 | 11/36 |
Doxycycline |
200 mg | Photosensitivity |
| Pterygium | ||||||
|
Rua O, Larrayoz IM, |
RCT | 2014 | 0/49 | Doxycycline | 200 mg | Phototoxicity |
| Register | ||||||
|
Lebrun‐Vignes B, Kreft‐Jais C. |
Pharmacovigilance register | 2012 |
69 18 1 1 |
Doxycycline Minociclyne Lymecycline Metacycline |
Not specified | Photosensitivity |