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Systemic administration of lipid‐CRISPR system cleared solid tumors through apoptotic pathway. (a) Binding sites for gRNAs on E6 and E7 genes of HPV. (b) gRNAs (18E7) + Cas9‐lipid effectively eliminated xenografts tumors derived from HeLa cells. (c) The apoptosis ratio was increased in 18E7 group. (d) The lipid‐CRISPR system prolonged mice survival in 18E7 group. Open achieved. Copyright © 2019 Elsevier B.V
