Table 2.
Association Between Revised Febrile Neutropenia Management Algorithm and Secondary Study Outcomes Standardized to 1,000 Patient Daysa
| Parameter | Coefficient (95% CI) | P Value |
|---|---|---|
| C. difficile infection rate | ||
| Preintervention slope (β 1) | −0.06 (−0.17 to 0.05) | .28 |
| Level change immediately following intervention (β 2) | 0.15 (−1.59 to 1.90) | .86 |
| Slope change following intervention (β 3) | 0.06 (−0.07 to 0.18) | .37 |
| Intervention trend (β 1 + β 3) | −0.004 (−0.06 to 0.05) | .90 |
| Bacterial bloodstream infection rate | ||
| Preintervention slope (β 1) | −0.02 (−0.23 to 0.18) | .84 |
| Level change immediately following intervention (β 2) | 3.30 (0.97 to 5.63) | .006 |
| Slope change following intervention (β 3) | −0.08 (−0.29 to 0.14) | .47 |
| Intervention trend (β 1 + β 3) | −0.10 (−0.17 to −0.03) | .006 |
| Gram-positive bacterial bloodstream infection rate | ||
| Preintervention slope (β 1) | 0.07 (−0.13 to 0.27) | .48 |
| Level change immediately following intervention (β 2) | 2.19 (−1.15 to 5.54) | .19 |
| Slope change following intervention (β 3) | −0.19 (−0.41 to 0.04) | .10 |
| Intervention trend (β 1 + β 3) | −0.12 (−0.23 to 0.01) | .03 |
| Gram-negative bacterial bloodstream infection rate | ||
| Preintervention slope (β 1) | −0.001 (−0.07 to 0.06) | .88 |
| Level change immediately following intervention (β 2) | 1.11 (−0.29 to 2.52) | .12 |
| Slope change following intervention (β 3) | 0.01 (−0.09 to 0.11) | .85 |
| Intervention trend (β 1 + β 3) | 0.01 (−0.07 to 0.82) | .89 |
| Intensive care unit length of stay in days (median) | ||
| Preintervention slope (β 1) | −0.08 (−0.19 to 0.04) | .18 |
| Level change immediately following intervention (β 2) | 0.62 (−0.79 to 2.03) | .38 |
| Slope change following intervention (β 3) | 0.05 (−0.07 to 0.17) | .44 |
| Intervention trend (β 1 + β 3) | −0.03 (−0.07 to 0.01) | .15 |
| Hospital all-cause mortality rate | ||
| Preintervention slope (β 1) | 0.07 (−0.04 to 0.19) | .20 |
| Level change immediately following intervention (β 2) | −1.54 (−3.45 to 0.38) | .11 |
| Slope change following intervention (β 3) | −0.03 (−0.16 to 0.09) | .60 |
| Intervention trend (β 1 + β 3) | 0.04 (−0.01 to 0.09) | .11 |
Note. CI, confidence interval.
a
Unless otherwise specified.