Figure 3.

High-confidence osteoarthritis effector genes

(A) Overview of the 77 high-confidence osteoarthritis effector genes and their broad biological classifications, as depicted in Tables 3 and S12. The lead SNV for each is given in brackets.

(B) Schematic representation of a chondrocyte and its extracellular matrix, highlighting exemplary osteoarthritis-implicated biological pathways (TGF-β signaling, FGFR3 signaling, and part of the fibrosis pathway) and the high-confidence effector genes (in red boxes), both established and newly identified (in red boxes with a black outline) that have been found to play a role.