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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Microbiol. 2021 May 23;62:14–20. doi: 10.1016/j.mib.2021.04.003

Figure 2. Model of intraspecies interactions between P. aeruginosa wild type (WT) and frequently observed lasR loss-of-function mutants (LasR−).

Figure 2.

In response to the siderophore pyochelin (blue hexagon) produced by LasR− strains, WT (LasR+) P. aeruginosa releases citrate (star). Citrate preferentially stimulates quorum sensing in LasR− strains (and not WT) by activating the downstream quorum-sensing regulator RhlR resulting in the increased production of phenazines (decagram) and other secreted factors [30].