Names and sequences of α-conotoxin variants synthesised in this study.
| Peptide name | Sequencea |
|---|---|
| EpI[Y(SO3)15Y]-OH | H-GCCSDPRCNMNNPDYC-OH |
| EpI-OH | H-GCCSDPRCNMNNPDY(SO3)C-OH |
| EpI[Y(SO3)15Y]-NH2 | H-GCCSDPRCNMNNPDYC-NH2 |
| EpI-NH2 (native) | H-GCCSDPRCNMNNPDY(SO3)C-NH2 |
| AnIB[Y(SO3)16Y]-OH | H-GGCCSHPACAANNQDYC-OH |
| AnIB-OH | H-GGCCSHPACAANNQDY(SO3)C-OH |
| AnIB[Y(SO3)16Y]-NH2 | H-GGCCSHPACAANNQDYC-NH2 |
| AnIB-NH2 (native) | H-GGCCSHPACAANNQDY(SO3)C-NH2 |
| PnIA[Y(SO3)15Y]-OH | H-GCCSLPPCAANNPDYC-OH |
| PnIA-OH | H-GCCSLPPCAANNPDY(SO3)C-OH |
| PnIA[Y(SO3)15Y]-NH2 | H-GCCSLPPCAANNPDYC-NH2 |
| PnIA-NH2 (native) | H-GCCSLPPCAANNPDY(SO3)C-NH2 |
a
C = oxidised cysteine (cystine); Y(SO3) = sulfotyrosine; N- and C-termini are shown in small capitals representing a primary amine at the N-terminus and either carboxylic acid or amide at the C-terminus.