IC50 of HUVECs by compounds 13b, 13d, 13j, 14a, 14c–14e, 14j, and 15g.
Sr. no. | Code | IC50a (μM) | A ring | B ring |
---|---|---|---|---|
1 | 13b | 2 | Phenyl | 2-Cl phenyl |
2 | 13d | >10 | Phenyl | 4-CF3 phenyl |
3 | 13j | >10 | Phenyl | 3,4-DiCl phenyl |
4 | 14a | >10 | 4-F phenyl | Phenyl |
5 | 14c | 0.7 | 4-F phenyl | 2-Furyl |
6 | 14d | 6 | 4-F phenyl | 4-CF3 phenyl |
7 | 14e | >10 | 4-F phenyl | 4-F phenyl |
8 | 14j | 2 | 4-F phenyl | 3,4-DiCl phenyl |
9 | 15g | >10 | 2,4-DiF phenyl | 4-Tolyl |
10 | STS | 0.5 | — | — |
Assays were performed in replicate (n ≥ 2).