Summary of findings 2. Summary of findings (Rotta preparation).
| Glucosamine versus placebo (Rotta preparation) for treating osteoarthritis | ||||||
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Patient or population: patients with treating osteoarthritis Settings: Intervention: Glucosamine versus placebo (Rotta preparation) | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Glucosamine versus placebo (Rotta preparation) | |||||
| Pain based on WOMAC scale Scale from: 0 (no pain) to 20 (worst pain). (follow‐up: mean 6 months) | The mean pain based on womac scale in the control groups was 6 points | The mean Pain based on WOMAC scale in the intervention groups was 3.33 lower (4.98 to 1.71 lower) | 940 (8) | ⊕⊕⊝⊝ low1,2 | Statistically significant. SMD ‐1.11 (‐1.66 to ‐0.57, see outcome 4.1). Relative per cent change from baseline is ‐42.2% (95% CI ‐63.0%, ‐21.6%). | |
| WOMAC Function Subscale Scale from: 0 to 68. (follow‐up: mean 6 months) | The mean womac function subscale in the control groups was 21.66 points | The mean WOMAC Function Subscale in the intervention groups was 2.07 lower (3.81 to 0.33 lower) | 624 (3) | ⊕⊕⊕⊕ high | Statistically significant. SMD ‐0.19 (‐0.35 to ‐0.03, see outcome 4.6). Relative per cent change from baseline is ‐7.6% (95% CI ‐14.0%, ‐1.2%). | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; | ||||||
| GRADE Working Group grades of evidance High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 High heterogeneity, I‐squared=92%
2 Funnel plot asymmetrical in favour of positive studies