Cibere 2004.

Methods	Randomized controlled trial Double blinded Discontinuation trial Multicenter trial Parallel group
Participants	Outpatients with OA of the knee Country: Canada N = 137 In order to qualify for study entry, subjects must have been users of glucosamine and have experienced at least a moderate improvement in knee pain since starting on glucosamine Mean age = 64.5 years Female: 60% Male: 40%
Interventions	GS = 1500 mg/day vs placebo for 24 weeks
Outcomes	Proportion of disease flares Time to disease flare and severity of disease flare WOMAC pain WOMAC stiffness WOMAC function WOMAC total Analgesic medication usage
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate