D'ambrosio 1981.

Methods	Randomized controlled trial Double blinded Single center Parallel group
Participants	Inpatients with chronic degenerative osteoarthrotic disorders (site not specified) Country: Italy N = 30 Mean age = 74.7 years Female: 77% Male: 23%
Interventions	GS 400 mg OD (IV or IM) for 7 days followed by two weeks of GS 500 mg PO TID versus (piperazine plus chlorbutanol) x 7 days followed two weeks of oral placebo Duration: 3 weeks
Outcomes	Pain (at rest) Pain (during passive range of motion ) Pain (active range of motion) 0 to 3 scale Functional limitation 0 to 3 scale Safety
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	High risk	C ‐ Inadequate