Herrero‐Beaumont 2007.

Methods	Randomized controlled trial Double blinded Multicenter Parallel group
Participants	Outpatients with primary symptomatic OA of the knee Country: Spain and Portugal N = 325 Mean age: 63.9 years 87% female 13% male
Interventions	GS 1500 mg/day versus acetaminophen 3 gm/day versus placebo Duration: 24 weeks
Outcomes	Lequesne Index, WOMAC total WOMAC pain, WOMAC function, OARSI A and B responder criteria, Global‐patient derived
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate