Houpt 1999.

Methods	Randomized controlled trial Double blinded Single center Parallel group
Participants	Outpatients with primary osteoarthritis of the knee Country: Canada N = 118 Mean age: 64.5 years Female: 62% Male: 38% Age range: 40 to 85 years
Interventions	GH 500 mg PO TID versus placebo PO TID Duration: 8 weeks with an additional 8 weeks follow‐up period (open label)
Outcomes	WOMAC Daily pain diary Global patient derived Improvement on knee examination Use of acetaminophen Perception as to what group the subject were randomized to Safety
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate