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. 2021 Sep 14;54(9):1961–1975.e5. doi: 10.1016/j.immuni.2021.08.011

Figure 6.

Figure 6

ISG induction in Adar1mZα/mZα mice is MAVS dependent

(A and B) Levels of the indicated mRNAs were analyzed using qRT-PCR in RNA samples extracted from tissues of WT and Adar1mZα/mZα animals that were either MAVS sufficient or deficient. Data are shown relative to Gapdh.

(C) Mice of the indicated genotypes were infected intranasally with 0.04 HAU of IAV strain A/X-31. Body weight was monitored daily and is shown as a percentage of starting body weight.

In (A) and (B), each dot represents an individual mouse, and pooled data from three independent experiments are shown (p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001, unpaired t test). In (C), data from two independent experiments including a total of 10–12 mice per genotype were pooled (mean with SD).