REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-ADAR1	Santa Cruz	Cat# sc-73408; RRID: AB_2222767
Anti-CD45.1-AF488 (clone A20)	Biolegend	Cat# 110718; RRID: AB_492862
Anti-CD45.2-AF488 (clone 104)	Biolegend	Cat# 109815; RRID: ΑΒ_492869
Anti-CD45.2-PE (clone 104)	Biolegend	Cat# 109808; RRID: AB_313445
Anti-CD11c-APC (clone N418)	eBioscience	Cat# 17-0114-81; RRID: ΑΒ_469345
Anti-CD11b-BV785 (clone M1/70)	Biolegend	Cat# 101243; RRID: AB_2561373
Anti-MHCII-AF700 (Clone M5/114.15.2)	eBioscience	Cat# 56-5321-80; RRID: AB_494010
Anti-CD24-BV605 (Clone M1/69)	Biolegend	Cat# 101827; RRID: AB_2563464
Anti-CD64-PE (Clone X54-5/7.1)	Biolegend	Cat# 139304; RRID: AB_10612740
Anti-MHCII-e780 (Clone M5/114.15.2)	eBioscience	Cat# 47-5321-82; RRID: AB_1548783
Anti-CD31-PEcy7 (Clone 390)	eBioscience	Cat# 25-0311-81; RRID: AB_2734962
Anti-CD326-APC (Clone G8.8)	eBioscience	Cat# 17-5791-80; RRID: AB_2734965
Anti-ly6G-AF700 (Clone 1A8)	Biolegend	Cat# 127622; RRID: AB_10643269
Anti-siglecF-BV421 (Clone E50-2440)	BD	Cat# 565934; RRID: AB_2739398
Bacterial and virus strains
Influenza A virus (A/X-31; A/HongKong/1/1968)	Laboratory of Alain R. Townsend	(Powell et al., 2019)
Chemicals, peptides, and recombinant proteins
Collagenase, type II	Worthington Biochemical	Cat# LS004204
Dnase I	Sigma Aldrich	Cat# D4263
LIVE/DEAD Fixable Aqua Dead Cell Stain Kit	Invitrogen	Cat# L34966
Recombinant mouse GM-CSF	Peprotech	Cat# 315-03
Critical commercial assays
RNeasy Plus Kit	QIAGEN	Cat# 74134
Mouse IL-6 Uncoated ELISA Kit	Life technology	Cat# 88-7064-88
Taqman Gene expression master mix	Life technology	Cat# 4304437
Deposited data
RNaseq analysis of WT and Adar1mZα/mZα mice	ENA	PRJEB45231
Experimental models: Cell lines
MDCK-SIAT cells for Influenza virus propagation	ECACC	Cat# 05071502
Experimental models: Organisms/strains
C57BL/6 mice	Envigo and University of Oxford Biomedical Services	N/A
Adar1mZα/mZα mice	This paper	N/A
B6SJLCD45.1 mice	University of Oxford Biomedical Services	N/A
Μavs−/− mice	Laboratory of J. Tschopp	Michallet et al., 2008
Oligonucleotides
Genotyping primer F 5′-TGACGAGA GACTTGTTTTCCTAGCATG-3′	Sigma	N/A
Genotyping primer R1 5′-TGCCTCAATGA GACCTCCAACTTAACTC-3′	Sigma	N/A
Genotyping prime R2WT 5′-CAG GGAGTACAAAATACGATT-3′	Sigma	N/A
Genotyping prime R2MUT 5′-CAG GGAGGCCAAAATACGAGC-3′	Sigma	N/A
Taqman probes and qPCR primers, see Table S2	This paper	N/A
Software and algorithms
GraphPad Prism v8	GraphPad Software	http://www.graphpad.com