Figure 1.

Behavioral effects following chronic fluoxetine treatment in control and corticosterone-treated mice in the OF test. Central time (A), number of central entries (B), total distance traveled (C). Three-way ANOVA analysis showed an effect of genotype and treatment in all OF parameters, an effect of the model in central activity, and a significant model × treatment interaction on total distance (Table S1, supplementary statistical report). Data are mean ± SEM: *p < 0.05, **p < 0.01, and ***p < 0.001 (Newman–Keuls post hoc test); ⁺p < 0.05; ⁺⁺⁺p < 0.001 (Student’s unpaired t-test).