Table 1.
Characterization of the study population and samples
| Characteristics | Atopic dermatitis | Healthy controls |
|---|---|---|
| Subjects analysed, N | 10 | 5 |
| Age, mean (range), years | 47 (24–62) | 48 (27–63) |
| Female:male ratio | 7:3 | 3:2 |
| SCORAD | ||
| Mean (range) | 31 (20–68) | NA |
| Moderate: Severe | 8:2 | NA |
| Filaggrin Mutation: Wt: Unknown | 4:1:5 | Unknown |
| HECSI, mean (range) | 10 (4–16) | NA |
| Treatment | ||
| No | 2 | 5 |
| Steroid | 5 | 0 |
| Systemic | 4 | 0 |
| Nizoral | ||
| Occasionally: likely after study participation | 1:1 | 0 |
| Co-morbidities | ||
| Asthma | 5 | 0 |
| Hay fever | 5 | 0 |
| CD | 5 | 1 |
| FA | 1 | 0 |
| Skin site successfully sampled, Nonlesional:lesional ratio | ||
| Nasal | 8:1 | 5 |
| Periorbital | 2:3 | 5 |
| Perioral | 4:4 | 5 |
| Neck | 2:3 | 5 |
| Upper inner arms | 0:2 | 3 |
| Antecubital fossae | 1:3 | 5 |
| Volar forearms | 0:2 | 3 |
| Dorsum of hands | 0:1 | 3 |
| Palmar hands | 3:2 | 3 |
| Between fingers | 0:5 | 5 |
| Popliteal flexures | 1:1 | 4 |
| Dorsum of feet | 0:2 | 5 |
| Arches of feet | 0:1 | 5 |
| Between toes | 6:2 | 5 |
The 14 skin areas sampled are listed in the top of the table and in detail include: The neck (the anterior triangle), and bilaterally from the anterior nares, periorbital and perioral areas, antecubital and popliteal flexures (midline +/− 5 cm), upper inner arms (starting after the flexural area ending before the armpit, before presence of hair follicles from the armpit), volar forearms (starting after the antecubital fossae to 4 cm from the wrist), dorsum of the hands and feet (from wrist to joints of the digits), the web spaces between the fingers and toes, palmar hands (from wrist to joints of the digits), and arches of the feet.
Abbreviations: AD atopic dermatitis, C control, M male, F female, SCORAD Severity Scoring Atopic Dermatitis, HECSI Hand Eczema Severity Index, FLG filaggrin gene, UN unknown, CD contact dermatitis, FA food allergy, WT wildtype, Mut mutation, NA not applicable.