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. 2021 Sep 22;19:401. doi: 10.1186/s12967-021-03079-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a qRT-PCR for the TACC2-FGFR2 fusion transcript in MKN45, NUGC4 cells and corresponding TACC2-FGFR2-expressing cells. Data are presented as mean ± SEM. * means P < 0.05, ** means P < 0.01. b IHC of MKN45, NUGC4 cells and corresponding TACC2-FGFR2-expressing cells for FGFR2 protein. Scale bar = 50 µm. MKN45T: TACC2-FGFR2-expression MKN45 cells. NUGC4T: TACC2-FGFR2-expression NUGC4 cells. c Sensitivity of MKN45, NUGC4 cells transfected with TACC2-FGFR2 or control plasmids to FGFR2 inhibitors, including BGJ398, AZD4547 and Erdafitinib. MKN45T: TACC2-FGFR2-expression MKN45 cells. NUGC4T: TACC2-FGFR2-expression NUGC4 cells