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. 2021 Sep 22;40:299. doi: 10.1186/s13046-021-02090-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Mettl3/IGF2BP1-mediated m⁶A modification is involved in the upregulation of LNCAROD. A Mettl3 expression in HCC was analyzed using the TCGA database. B RIP-RT-qPCR assay results show the enrichment of m⁶A-modified LNCAROD in SNU-449 and HCC-LM3 cells compared with THLE2 cells. C-D Effect of Mettl3 knockdown or overexpression on LNCAROD expression. E RIP-RT-qPCR results show the enrichment of m⁶A-modified LNCAROD following Mettl3 depletion. F LNCAROD stability analysis in HCC-LM3 cells with Mettl3 silencing or overexpression in the presence of actinomycin D. G RIP-RT-qPCR assay results show the enrichment of the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) on LNCAROD in HCC cells. H-I Effect of IGF2BP1 knockdown or overexpression on LNCAROD expression. J LNCAROD stability analysis in HCC-LM3 cells with IGF2BP1 silencing or overexpression in the presence of actinomycin D. K RIP-RT-qPCR assay results show the enrichment of IGF2BP1 on LNCAROD upon Mettl3 silencing. Data are shown as the mean ± SD. ^*P < 0.05; ^**P < 0.01