Fig. 7.

LNCAROD plays a more important role in mediating HCC tumorigenesis under hypoxia than normoxia. A CCK-8 cell viability, B colony formation, C migration and invasion, D glucose consumption, E lactate production, F ATP production, G ECAR, H PKM2 mRNA expression, and I PKM2 protein expression assays in SMMC-7721 and Huh7 cells transfected with the vector or LNCAROD under normoxia (20 % O₂) or hypoxia (1 % O₂ or in the presence of CoCl₂). Data are shown as the mean ± SD. ^*P < 0.05; ^**P < 0.01