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. 2021 Sep 23;112:300–317. doi: 10.1016/j.ijid.2021.09.045

Table 1.

Features of 20th and 21st century influenza pandemics

Pandemic Dates Influenza virus No. waves No. deaths Age groups with highest mortality
Spanish influenza 1918–1920 A/H1N1 3(Barry, 2005) 20–100 million (Barry, 2005, Johnson and Mueller, 2002, Jordan, 1927, Nicholson et al., 2019) Infants, young adults (20–40 years), elderly (Taubenberger and Morens, 2006)
Asian influenza 1957–1958 A/H2N2 2(Rogers 2020) 1–2 million (Saunders-Hastings and Krewski, 2016) Infants, children (5–14 years), young adults (15–24 years), elderly (Viboud et al., 2016)
Hong Kong influenza 1968–1969 A/H3N2 2(Cockburn et al., 1969, Saunders-Hastings and Krewski, 2016) 0.5–2 million (Saunders-Hastings and Krewski, 2016) >65 years (Centers for Disease Control and Prevention 2019b)
Russian influenza 1977–1979 A/H1N1 1(Gregg et al., 1978) 700,000 (Gregg et al., 1978) Infants, young adults (<25 years) (Gregg et al., 1978)
Swine influenza 2009–2010 A/H1N1pdm09 2 or 3 depending on location(Jhung et al., 2011, Saunders-Hastings and Krewski, 2016) 123,000–203,000 (Simonsen et al., 2013) 5–59 years (Charu et al., 2011)