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. 2021 Sep 9;8:721990. doi: 10.3389/fmolb.2021.721990

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Copyright © 2021 Zang, Wang, Wang, Li, Xia, Liu, Chen, Piao, Qi and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic adaptions related with a highly expressed ILF2 and ILF3 in ESCC. (A). Heatmap analysis of differential metabolites according to the expression of ILF2 in ESCC tissues. Patients in group Ⅱ exhibited higher ILF2 levels in tumor tissues than those in the para-tumor tissues, and other cases were in group Ⅰ. (B). Alterations of acyl-carnitines in ESCC cases with (n = 13, group Ⅱ) or without (n = 15, group Ⅰ) highly expressed ILF2 in tumor tissues. (C). Heatmap analysis of differential metabolites according to the expression of ILF3 in ESCC tissues. Patients in group Ⅳ exhibited higher ILF3 levels in tumor tissues than those in the para-tumor tissues and others were in group Ⅲ. (D). Influenced glycolysis pathway in ESCC cases with (n = 16, group Ⅳ) or without (n = 12, group Ⅲ) highly expressed ILF3 in tumor tissues. Data were expressed as mean ± SEM.