Table 1.
Age-adjusted early-onset (20-49 years of age) colorectal cancer incidence rates per 100,000 person-years.
| Age 20-49 Years | 2001-2002 | 2017-2018 | Trend 1 | Trend 2 | Joinpoint 1 | AAPC | AAPC 95% CI | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Rate | 95% CI | IRR | 95% CI | Cases | Rate | 95% CI | IRR | 95% CI | APC (%) | APC (%) | (%) | |||
| All Colorectal Cancer | |||||||||||||||
| Non-Hispanic White | 17,299 | 9.82 | (9.67, 9.97) | 1.00 | – | 17,732 | 12.50 | (12.32, 12.69) | 1.00 | – | 1.62* | 1.62* | (1.41, 1.82) | ||
| Non-Hispanic Black | 3,794 | 13.05 | (12.63, 13.47) | 1.33 | (1.28, 1.38) | 4,137 | 13.26 | (12.85, 13.67) | 1.06 | (1.02, 1.10) | 0.05 | 0.05 | (-0.24, 0.35) | ||
| Hispanic | 2,247 | 8.00 | (7.67, 8.34) | 0.81 | (0.78, 0.85) | 4,629 | 10.02 | (9.73, 10.31) | 0.80 | (0.78, 0.83) | 0.28 | 3.61 | 2013-2014 | 1.10* | (0.14, 2.07) |
| American Indian/Alaskan Native | 186 | 9.32 | (8.03, 10.76) | 0.95 | (0.82, 1.10) | 290 | 15.11 | (13.41, 16.95) | 1.21 | (1.08, 1.36) | 3.13* | 3.13* | (2.29, 3.98) | ||
| Asian/Pacific Islander | 1,008 | 9.03 | (8.48, 9.61) | 0.92 | (0.86, 0.98) | 1,701 | 9.63 | (9.18, 10.10) | 0.77 | (0.73, 0.81) | 0.37 | 0.37 | (-0.03, 0.78) | ||
| Proximal Colon Cancer | |||||||||||||||
| Non-Hispanic White | 4,888 | 2.78 | (2.70, 2.86) | 1.00 | – | 4,198 | 2.95 | (2.86, 3.04) | 1.00 | – | 0.44* | 0.44* | (0.20, 0.67) | ||
| Non-Hispanic Black | 1,408 | 4.85 | (4.60, 5.11) | 1.75 | (1.64, 1.85) | 1,462 | 4.70 | (4.46, 4.95) | 1.59 | (1.50, 1.69) | -0.21 | -0.21 | (-0.53, 0.10) | ||
| Hispanic | 641 | 2.28 | (2.10, 2.46) | 0.82 | (0.75, 0.89) | 1,176 | 2.55 | (2.41, 2.70) | 0.86 | (0.81, 0.92) | -0.57 | 3.51 | 2013-2014 | 0.43 | (-0.88, 1.77) |
| American Indian/Alaskan Native | 49 | 2.45 | (1.81, 3.23) | 0.88 | (0.66, 1.17) | 56 | 2.90 | (2.18, 3.76) | 0.98 | (0.75, 1.28) | 1.47 | 1.47 | (-0.11, 3.07) | ||
| Asian/Pacific Islander | 274 | 2.43 | (2.15, 2.74) | 0.88 | (0.78, 0.99) | 361 | 2.03 | (1.82, 2.25) | 0.69 | (0.62, 0.77) | -0.57 | -0.57 | (-1.40, 0.26) | ||
| Distal Colon Cancer | |||||||||||||||
| Non-Hispanic White | 4,654 | 2.64 | (2.56, 2.71) | 1.00 | – | 5,137 | 3.63 | (3.53, 3.73) | 1.00 | – | 2.16* | 2.16* | (1.91, 2.41) | ||
| Non-Hispanic Black | 983 | 3.38 | (3.17, 3.60) | 1.28 | (1.20, 1.37) | 1,075 | 3.45 | (3.25, 3.67) | 0.95 | (0.89, 1.02) | 0.19 | 0.19 | (-0.27, 0.66) | ||
| Hispanic | 577 | 2.09 | (1.92, 2.27) | 0.79 | (0.73, 0.86) | 1,342 | 2.91 | (2.75, 3.07) | 0.80 | (0.75, 0.85) | 1.43* | 1.43* | (0.60, 2.27) | ||
| American Indian/Alaskan Native | 52 | 2.60 | (1.94, 3.41) | 0.99 | (0.75, 1.30) | 85 | 4.40 | (3.51, 5.44) | 1.21 | (0.98, 1.50) | 3.07* | 3.07* | (0.82, 5.37) | ||
| Asian/Pacific Islander | 269 | 2.44 | (2.16, 2.75) | 0.93 | (0.82, 1.05) | 523 | 2.97 | (2.72, 3.23) | 0.82 | (0.75, 0.89) | 0.47 | 0.47 | (-0.32, 1.27) | ||
| Rectal Cancer | |||||||||||||||
| Non-Hispanic White | 6,910 | 3.92 | (3.83, 4.02) | 1.00 | – | 7,732 | 5.45 | (5.33, 5.58) | 1.00 | – | 2.17* | 2.17* | (1.87, 2.46) | ||
| Non-Hispanic Black | 1,144 | 3.93 | (3.70, 4.16) | 1.00 | (0.94, 1.07) | 1,396 | 4.45 | (4.22, 4.70) | 0.82 | (0.77, 0.86) | 0.58 | 0.58 | (-0.34, 1.50) | ||
| Hispanic | 896 | 3.18 | (2.97, 3.40) | 0.81 | (0.76, 0.87) | 1,887 | 4.07 | (3.89, 4.26) | 0.75 | (0.71, 0.79) | 0.61 | 3.98 | 2013-2014 | 1.44* | (0.57, 2.32) |
| American Indian/Alaskan Native | 74 | 3.72 | (2.92, 4.67) | 0.95 | (0.75, 1.19) | 135 | 7.12 | (5.96, 8.42) | 1.30 | (1.10, 1.55) | 4.04* | 4.04* | (2.87, 5.23) | ||
| Asian/Pacific Islander | 423 | 3.77 | (3.42, 4.15) | 0.96 | (0.87, 1.06) | 763 | 4.34 | (4.03, 4.65) | 0.79 | (0.74, 0.86) | 0.93* | 0.93* | (0.37, 1.50) | ||
*Statistically significant at the 0.05 level.
IRR, incidence rate ratio; CI, confidence interval; APC, annual percent change; AAPC, average annual percent change.