Table 3.

Age‐adjusted early‐onset (20-49 years of age) and late‐onset (50-74 years of age) colorectal adenocarcinoma rates per 100,000 person‐years.

All Colorectal Cancer	2001-2002					2017-2018					Trend 1	Trend 2	Joinpoint 1	AAPC	AAPC 95% CI
	Cases	Rate	95% CI	IRR	95% CI	Cases	Rate	95% CI	IRR	95% CI	APC (%)	APC (%)		(%)
20-49 Years
Non-Hispanic White	15,641	8.87	(8.73, 9.01)	1.00	–	16,093	11.36	(11.18, 11.53)	1.00	–	1.69*			1.69*	(1.50, 1.89)
Non-Hispanic Black	3,273	11.26	(10.88, 11.65)	1.27	(1.22, 1.32)	3,465	11.13	(10.76, 11.51)	0.98	(0.94, 1.02)	-0.02			-0.02	(-0.30, 0.25)
Hispanic	1,962	7.01	(6.70, 7.34)	0.79	(0.75, 0.83)	4,048	8.78	(8.51, 9.05)	0.77	(0.75, 0.80)	1.05*			1.05*	(0.43, 1.68)
American Indian/Alaskan Native	166	8.33	(7.11, 9.70)	0.94	(0.81, 1.09)	258	13.42	(11.82, 15.16)	1.18	(1.04, 1.34)	3.07*			3.07*	(2.31, 3.83)
Asian/Pacific Islander	888	7.96	(7.44, 8.50)	0.90	(0.84, 0.96)	1,502	8.51	(8.09, 8.96)	0.75	(0.71, 0.79)	0.35			0.35	(-0.06, 0.75)
50-74 Years
Non-Hispanic White	115,547	118.15	(117.47, 118.84)	1.00	–	101,799	74.26	(73.80, 74.73)	1.00	–	-3.72*	1.54*	2011-2012	-2.91*	(-3.28, -2.53)
Non-Hispanic Black	15,905	138.59	(136.43, 140.77)	1.17	(1.15, 1.19)	18,810	90.32	(89.02, 91.64)	1.22	(1.20, 1.24)	-2.82*			-2.82*	(-3.13, -2.51)
Hispanic	8,109	96.14	(94.04, 98.28)	0.81	(0.80, 0.83)	14,163	71.02	(69.83, 72.22)	0.96	(0.94, 0.97)	-1.97*			-1.97*	(-2.33, -1.61)
American Indian/Alaskan Native	692	98.44	(91.05, 106.25)	0.83	(0.77, 0.90)	1,170	85.75	(80.84, 90.88)	1.15	(1.09, 1.22)	-0.74*			-0.74*	(-1.17, -0.30)
Asian/Pacific Islander	3,727	88.30	(85.46, 91.21)	0.75	(0.72, 0.77)	6,050	62.24	(60.66, 63.84)	0.84	(0.82, 0.86)	-2.12*			-2.12*	(-2.26, -1.98)

*Statistically significant at the 0.05 level.

IRR, incidence rate ratio; CI, confidence interval; APC, annual percent change; AAPC, average annual percent change.